The Myeloma Globulins
نویسندگان
چکیده
منابع مشابه
Lambda Myeloma Globulins
210 Blood, Vol. 39, No. 2 (February), 1972 Blood obtained from seven patients with lambda type myeloma proteins showed evidence of gelatinous bulky clots, impaired clot retraction, and circulating anticoagulant activity associated with interference of fibrin monomer polymerization. Five patients had G1 and two had A1 myeloma proteins. The pathologic plasmas and isolated myeloma proteins had ant...
متن کاملThe Metabolism of Gamma Globulins in Myeloma and Allied Conditions.
Previous investigations of the turnover of normal and "pathological" gamma globulins using radioisotopically in vitro trace-labeled proteins in patients with multiple myeloma, macroglobulineniia, and benign M-type hypergammaglobulinemia (1-10) have yielded different results. The present study was undertaken to delineate and compare simultaneously the metabolism of normal gamma globulin and M-co...
متن کاملGenetic Characters of Human Γ-globulins in Myeloma Proteins
The genetic factors Gm(a), Gm(b), Gm(x), and Inv(a), Inv(b) described for normal human gamma-globulin were all found in different myeloma proteins. A single myeloma protein never contained more than one product of alternate alleles even in heterozygous individuals. However, factors determined by the two different loci were often found in the same myeloma protein. The Gm(a) character of the myel...
متن کاملDistinctive myeloma globulins associated with a new plasma cell neoplasm of strain C3H mice.
supplied experimental models analogous to multiple myeloma in man. In the initial reports of Rask-Nielsen and Gormsen,’ Bichel2 and Dunn3 on the occurrence of plasma-cell neoplasms in mice, serum protein observations are not mentioned. In 1957 Potter, Fahey and Pilgrim4 reported the first instance of marked serum protein abncrmalities, similar to those seen in multiple myeloma in man, associate...
متن کاملPotent in vitro and in vivo effects of polyclonal anti-human-myeloma globulins
INTRODUCTION Multiple myeloma is still incurable in most cases. Polyclonal anti T lymphocyte globulins (ATG) have been reported to kill human myeloma cells in vitro and in mouse models. METHODS Anti-human-myeloma globulins (AMG) were produced by immunizing rabbits with human myeloma cell lines RPMI-8226 (AMG-8226) or KMS-12-BM (AMG-12-BM). Cytotoxicity of the polyclonal antibodies was analyze...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1960
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1960.80